INOVIO has demonstrated that DNA medicines can be delivered directly into cells in the body via a proprietary smart device to safely produce a robust immune response in clinical trials involving more than 2,000 patients in 7,000 administrations. The advantages of INOVIO’s DNA medicines platform in a pandemic situation like the world is now facing with COVID-19 are how fast DNA medicines can be designed and manufactured; the stability of the products, which do not require frozen storage and transport; and their robust immune response as well as favorable safety and tolerability profile.
INOVIO scientists are coronavirus experts. INOVIO was the first to advance its DNA vaccine INO-4700 against MERS CoV, a related coronavirus, into evaluation in humans. INOVIO is currently preparing to initiate a Phase 2 vaccine trial for INO-4700 in the Middle East where most MERS viral outbreaks have occurred.
In a recently published paper in Lancet Infectious Diseases, INOVIO’s Phase 1 study of its MERS-CoV vaccine demonstrated it was well tolerated and furthermore induced high levels of antibody responses in roughly 95% of study participants. Durable antibody and T cell immune responses to INO-4700 were also maintained through 60 weeks following dosing.
INOVIO has assembled a global coalition of collaborators, partners and funders to rapidly advance INO-4800:
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