Intradermal Delivery
Inovio has existing products for intradermal DNA delivery, described below, and is actively developing sophisticated new intradermal delivery solutions.
Elgen® DNA Delivery System
The Elgen® DNA Delivery System is a newer generation of electroporation systems developed by Inovio. The system consists of a pulse generator and a tethered electrode array which is designed to be positioned on the surface of the skin following a standard intradermal injection of the DNA vaccine. Using a remote trigger, low voltage pulses are generated by the pulse generator and delivered to the skin through the multi-electrode array.
Output characteristics: 5-200 volts, 0.001-1 second
More information about this novel, minimally invasive intradermal electroporation device can be found in the manuscript Broderick et al, 2010 Gene Therapy.
CELLECTRA® DNA Delivery System
The CELLECTRA® electroporation device was designed to deliver DNA vaccines intramuscularly and intradermally. This device measures tissue resistance and adapts electrical output to varying individual conditions, such as fat content in the muscle, skin thickness, or changing tissue resistance during the electroporation process. By sensing the tissue micro-environment and adapting an applied, constant-current electric field strength in real-time, this technology optimizes DNA uptake and results in uniform expression of the target protein with minimal tissue damage. The device is portable, water-resistant, shock-proof, battery operated, and software driven, making it particularly suited for usage in the field and for veterinary applications.
Output characteristics: 40-200 Volts/cm, 52 msec
Current Range: 0.1-1.0 amps; optimal: 0.2 amps (intradermal)
CELLECTRA® DNA Delivery System 3000 Device - Prototype in development
