Industry, academic and government

Inovio has forged partnerships with pharma companies, government agencies and leading academic institutions to support the development of synthetic vaccines delivered via Inovio’s electroporation technology in many disease areas. Our strategy is to focus on our core expertise, conducting R&D and clinical development to achieve proof of principle of SynCon® vaccine products, and engage with partners to complete late-stage clinical development and commercialization and, in some cases, advance early-stage programs. We currently have advancing discussions with funding agencies and pharma/vaccine companies with the intent of securing funding and sponsorship for R&D and early clinical studies as well as more comprehensive development and partnering relationships.


Roche & Inovio

Roche acquired an exclusive worldwide license to develop and commercialize Inovio’s hepatitis B (INO-1800) immunotherapy. Roche has exclusively licensed this DNA-based product and the use of Inovio’s CELLECTRA® electroporation technology for delivery of the product.

Under the terms of the agreement, Roche made an upfront payment of USD $10 million to Inovio, in part, for the hepatitis b rights. Roche will also provide preclinical R&D support and payments for near-term regulatory milestones as well as payments upon reaching certain development and commercial milestones. Additional development milestone payments could also be made to Inovio if Roche pursues other indications with INO-1800. In addition, Inovio is entitled to receive up to double-digit tiered royalties on product sales.

University of Pennsylvania (UPenn)

University of Pennsylvania

Inovio’s partnership with the University of Pennsylvania is the major source of Inovio’s synthetic vaccine research and development. The underlying technology was developed in the laboratory of Professor David B. Weiner, Ph.D., at UPenn. Dr. Weiner is a pioneer in the field of DNA vaccines and serves as chairman of Inovio’s Scientific Advisory Board.
His lab continues to design new preventive and therapeutic SynCon® vaccines for cancers and infectious diseases.  

In 2007, Inovio (through VGX Pharmaceuticals, with which it merged in 2009) entered into an original research agreement with UPenn. The Company subsequently licensed from UPenn exclusive worldwide rights to develop a number of DNA plasmids and constructs with the potential to treat and/or prevent human immunodeficiency virus (HIV); hepatitis C virus (HCV); human papilloma virus (HPV), and influenza, and later an amended agreement adding novel adjuvants to enhance the effectiveness of DNA vaccines.

In 2011, Inovio expanded its existing license agreement with the University of Pennsylvania, adding exclusive worldwide licenses for technology and intellectual property for novel DNA vaccines against prostate cancer, CMV (cytomegalovirus), malaria, hepatitis B, RSV (respiratory syncytial virus), and MRSA (methicillin-resistant staphylococcus aureus). The amendment also encompassed a new optimized IL-12 cytokine gene adjuvant. 

Inovio expanded its existing license agreement with the University of Pennsylvania again in 2012, adding exclusive worldwide licenses to develop DNA vaccines against C. difficile, Wilms’ tumor gene, and filoviruses Ebola and Marburg 

The University of Pennsylvania has also conducted clinical studies for Inovio's PENNVAX®-B HIV DNA vaccine in a therapeutic setting.


Inovio has partnered with MedImmune, the global biologics research and development arm of AstraZeneca, to develop and assess DNA-based monoclonal antibodies (mAbs) for influenza and antibiotic resistant bacteria. Funded by a $12.2 million grant from the Defense Advanced Research Projects Agency (DARPA), Inovio and MedImmune aim to demonstrate that the DNA plasmids containing optimized DNA sequences encoded to generate disease-specific mAbs can activate sufficient quantities of specific antibodies in the body to be protective against a pathogen challenge. This collaboration also involves scientists from the Perelman School of Medicine at the University of Pennsylvania.

Drexel University

Drexel & Inovio

Inovio entered into a license agreement with Drexel University in 2013 for a novel Clostridium difficile DNA vaccine. This technology is co-owned by the University of Pennsylvania and was developed in the lab of Dr. Michele Kutzler.

Fudan University

Fudan University

In 2013, Inovio acquired worldwide rights (excluding China) for iTreg technology with the potential to address Alzheimer's disease and multiple sclerosis from Fudan University's Shanghai Medical College. The technology is based on patent-protected and published discoveries from Dr. Bin Wang of Fudan University and his collaborator, who found a novel way to generate inducible regulatory T cells.

HIV Vaccine Trials Network

HIV Vaccine Trials Network

The HIV Vaccine Trials Network (HVTN) funded and conducted clinical trials of Inovio's PENNVAX®-B HIV DNA vaccine candidate. The HVTN will also assist Inovio in the clinical trial for Inovio’s PENNVAX®-GP HIV DNA vaccine candidate.


The National Institute of Allergy and Infectious Diseases of the National Institutes of Health

The National Institute of Allergy and Infectious Diseases of the National Institutes of Health is providing $23.5 million of funding over seven years (ending 2015), including a base period and follow-on option years, to develop Inovio's PENNVAX®-GP vaccine candidate targeting HIV clades A, C, and  B and its novel intradermal electroporation (ID-EP) technology.

U.S. Military HIV Research Program

U.S. Military HIV Research Program; US Army

The U.S. Military HIV Research Program (MHRP) is conducting an NIAID-sponsored Phase I study, called RV262, to evaluate a combination DNA prime (PENNVAX®-G)/MVA vector boost regimen that was developed to protect against diverse subtypes of HIV-1 prevalent in North America, Europe, Africa, and South America.

PATH Malaria Vaccine Initiative

PATH Malaria Vaccine Initiative

The PATH Malaria Vaccine Initiative (MVI), established in 1999 through a grant from the Bill & Melinda Gates Foundation, is funding preclinical development of Inovio's SynCon® synthetic vaccine with respect to malaria.

National Cancer Institute

National Cancer Institute

Under a 2007 co-development agreement with Inovio, the National Cancer Institute is evaluating novel HIV constructs in non-human primates, cytokine genes as vaccine adjuvants (immune system stimulants), and possibly anticancer therapies delivered using Inovio's electroporation-mediated DNA delivery technology.